Joseph is a Professor in the EECS department at UC Berkeley, a co-director and founding member of the UC Berkeley Sky Computing Lab, RISE Lab, and a member of the Berkeley AI Research (BAIR Group). His research interests span artificial intelligence and data systems and he has a wide range of active research projects projects.

Joseph is a co-founder of Berkeley AI startup RunLLM. Prior to joining Berkeley, Joseph co-founded Turi Inc. (formerly GraphLab), which was based on his thesis work on the GraphLab and PowerGraph Systems. Turi was eventually acquired by Apple.